rifabutin will reduce the extent or influence of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.cyclophosphamide will raise the stage or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.En gruppe legemidler som motvirker depresjon ved å øke